In some cases, central hyperpigmentation was identified. Atypical pityriasis rosea associated with mRNA COVID19 vaccine E. Bostan, Adam Jarbou Published 29 September 2021 Medicine Journal of Medical Virology Variable dermatological manifestations including acral erythema, urticaria, vasculitis, vesicular or pustular eruptions, maculopapular rash have all been reported during the course of Covid-19. The exanthem was self-limited in both patients over a period of a month. Human herpesvirus-6,7, and Epstein-Barr virus reactivation in pityriasis rosea during COVID-19. -, Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI. Epub 2020 Jun 29. If you have pityriasis rosea, it can generally be well-managed without any treatment. Pityriasis Rosea as a Possible Complication of Vaccination Against COVID-19. Moreover, central dusky-red erythematous was observed on some plaques (Figure 2A). Please enable it to take advantage of the complete set of features! This site needs JavaScript to work properly. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. official website and that any information you provide is encrypted Shingles was another fear, as I had chicken pox when I was four, but we ruled that out too: "Shingles is a nerve-mediated process; it tends to be very painful, not so itchy," Lam says. doi: 10.1111/jdv.17342. This site needs JavaScript to work properly. JAAD Case Rep. 2021;7:9394. Factors affecting the severity of central centrifugal cicatricial alopecia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Lessons: To the best of our knowledge, only one case of ChAdOx1 nCoV-19 vaccine-induced PR-like eruption has been reported (2). doi: 10.1111/ijd.15700, 4. No one knows what causes pityriasis rosea, though healthcare experts think a virus might be responsible. SARS-CoV-2 spike protein positivity in pityriasis rosea-like and urticaria-like rashes of COVID-19. Treatment was initiated with systemic corticosteroid therapy - hydrocortisone hemisuccinate 200 mg/day for 7 days, and loratadine 10 mg 2 times a day. "Like a lot of things in dermatology, unfortunately, we're not always sure what causes these rashes," says Lam. and transmitted securely. Pityriasis rosea-like eruption presenting as multiple discrete erythematous oval patches and plaques on the back (A) lower abdomen, and bilateral upper thighs (B); lesions distributed along cleavage lines without prominent scales (C). Dermatology. doi: 10.1111/ijd.13061. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291919/). doi: 10.1111/bjd.20143. doi: 10.1111/dth.13878, 10. Many Americans become infected with them at an early age. The patient had a positive RT-PCR result, and was confirmed with SARS-CoV-2 infection. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. Pityriasis rosea (PR) is an acute papulosquamous cutaneous disorder that classically presents with a herald patch rapidly followed by a widespread rash along skin cleavage lines. 2021;184(6):11941195. Cured meats with nitrates, such as hot dogs. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. Dermatol Online J. Get useful, helpful and relevant health + wellness information. Unauthorized use of these marks is strictly prohibited. Would you like email updates of new search results? Indian J Dermatol 2016;61:37584. It was found on younger COVID-19 patients suffering milder forms of the virus. Epub 2021 May 29. Healthcare experts believe herpesvirus 6 (HHV-6), HHV-7 and/or HHV-8 cause pityriasis rosea, but there arent any conclusive studies. The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author/s. Atzori L, Pinna AL, Ferreli C, Aste N. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. -, Broccolo F., Drago F., Careddu A.M., et al. -, Carballido Vzquez AM, Morgado B. Pityriasis rosea-like eruption after PfizerBioNTech COVID-19 vaccination. Disseminated erythematous-papulosquamous lesions, with right. Temiz SA, Abdelmaksoud A, Dursun R, Durmaz K, Sadoughifar R, Hasan A. J Cosmet Dermatol. MeSH Parakeratosis with minimal acanthosis, MeSH Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. The patients/participants provided their written informed consent to participate in this study. A few days later, the cluster came: Ten little dots arranged themselves in a perfect alien-like crop circle on my upper back, and they itched so much that I scratched them raw. For most people, it resolves without treatment. Figure 3. This tiny glimpse of her natural texture is thrilling. In my experience, patients with darker skin are more likely to present with atypical forms of the disorder. doi: 10.1097/MD.0000000000029823. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Pityriasis Rosea Following Pfizer-BioNTech Vaccination in an Adolescent Girl. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). -, Johansen M, Chisolm SS, Aspey LD, Brahmbhatt M. Pityriasis rosea in otherwise asymptomatic confirmed COVID-19-positive patients: a report of 2 cases. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. In: Knoop KJ, Stack LB, Storrow AB, et al., eds. "Covid arm," a red, rashlike skin reaction that can occur at the injection site days after inoculation, has been well-publicized. -, Broccolo F, Drago F, Careddu AM, et al. Due to the temporal relationship between vaccination and onset of rash, COVID-19 vaccination was the most likely etiology. (2020) 33:e13878. Among 171 laboratory-confirmed COVID-19 patients with cutaneous manifestations from the registry, the most commonly reported were morbilliform rash (22 percent), pernio-like acral lesions (18 percent), urticaria (16 percent), macular erythema (13 percent), vesicular eruption (11 percent), papulosquamous eruption (9.9 percent), and retiform Influenza viruses and vaccines have triggered pityriasis rosea in some cases.". government site. When to test for COVID-19 using real-time reverse transcriptase polymerase chain reaction: a systematic review. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Vaccine-induced pityriasis rosea and pityriasis rosea-like eruptions: a review of the literature. Epub 2022 Feb 9. These patches are smaller than the herald patch they range from 1 to 2 cm and are often called daughter patches. "And it has a particular [dermatomal] distribution because it's along a nerve," which also presents as fluid-filled blisters, rather than lesions. Bookshelf Accessibility . The https:// ensures that you are connecting to the However, several adverse effects of COVID-19 vaccination have been identified. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. Fried foods, including many fast-food items. Pityriasis rosea-like rash after messenger RNA COVID-19 vaccination: A case report and review of the literature. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. Pityriasis rosea is a common condition that causes discolored patches on your skin. Marcantonio-Santa Cruz OY, Vidal-Navarro A, Pesqu D, Gimnez-Arnau AM, Pujol RM, Martin-Ezquerra G. J Eur Acad Dermatol Venereol. An official website of the United States government. and transmitted securely. doi: 10.1002/jmv.26549, 9. Authors B M Cyrenne 1 , F Al-Mohammedi 1 , J G DeKoven 1 , R Alhusayen 1 Affiliation Pityriasis rosea isnt a sexually transmitted disease or infection (STD or STI). JAAD Int. JAAD Case Rep 2018; 4: 800801. Outcome: Pityriasis rosea is a benign inflammatory rash that starts with a single red rash, also known as the "herald patch," which eventually gives way to a larger, similar-looking rash on the trunk within days or weeks, says dermatologist Corey L. Hartman, founder of Skin Wellness Dermatology in Birmingham, Alabama. "However, it's possible to develop the rash more than once," she says. 2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Common causes of drug-induced PR-like eruptions include angiotensin-converting enzyme inhibitors, non-steroidal anti-inflammatory drugs, and gold. Received: 03 August 2021; Accepted: 17 August 2021; Published: 07 September 2021. Federal government websites often end in .gov or .mil. The available COVID-19 vaccines entail different levels of risk for skin reactions. The symptoms of pityriasis rosea usually develop in stages: Pityriasis rosea doesnt hurt. While home remedies are safe for most people, its a good idea to check with your healthcare provider before trying some of the following options. Pityriasis Lichenoides. J Eur Acad Dermatol Venereol. It said blood spots under the skin might also be present, either as spots or dots or on larger areas. An official website of the United States government. official website and that any information you provide is encrypted The authors of one 2014 case report of a 71-year-old man who suffered from pityriasis rosea one month after receiving an influenza vaccine concluded that "altered immunity" could result in reactivation of HHV-6 and/or HHV-7 which may have triggered an atypical presentation of PR. Cazzato G, Ambrogio F, Pisani MC, Colagrande A, Arezzo F, Cascardi E, Dellino M, Macorano E, Trilli I, Parente P, Lettini T, Romita P, Marzullo A, Ingravallo G, Foti C. Vaccines (Basel). However, there isnt enough research to determine that stress may cause pityriasis rosea. doi: 10.1111/jdv.17316, PubMed Abstract | CrossRef Full Text | Google Scholar, 2. It has been reported that pityriasis rosea has been triggered by several vaccines, as a rare side-effect. Please enable it to take advantage of the complete set of features! J Med Virol 2021; 93: 18501851. The significance of investigating clinical, histopathologic and virological features in pityriasis rosea and pityriasis rosea-like eruptions following COVID-19 vaccinations. sharing sensitive information, make sure youre on a federal government site. In addition to COVID-19 vaccination, she was currently taking medications (i.e., levetiracetam and thyroxin) for glioblastoma, and the two drugs had been prescribed for approximately nine months. Ciccarese G, Parodi A, Drago F. SARS-CoV-2 as possible inducer of viral reactivations. Epub 2022 Jan 31. Pityriasis Rosea According to the Mayo Clinic, pityriasis rosea is a rash that usually begins as a large circular or oval spot on your chest, abdomen, or back. "It looks very different.". Sriphojanart T, Khunkhet S, Suchonwanit P. A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata. The site is secure. Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. . The .gov means its official. Cutaneous manifestation has been reported in 0.2% of patients infected by COVID-19 in China, and 18 out of 88 patients from Italy. 2020 Sep 25;155(6):273. doi: 10.1016/j.medcli.2020.05.024. J Am Acad Dermatol. Adverse cutaneous reactions following COVID-19 vaccines have increased, highlighting not only how SARS-CoV-2 infection but also COVID-19 vaccines may induce adverse cutaneous manifestations. And the itch usually only lasts for a few days mine finally let up around day seven but the rash can leave behind dark marks that eventually resolve on their own, Lam says. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. New York City-based dermatologist Macrene Alexiades. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. 2022 by the American Academy of Dermatology, Inc. Careers. Before Busto-Leis JM, Servera-Negre G, Mayor-Ibarguren A, Sendagorta-Cuds E, Feito-Rodrguez M, Nuo-Gonzlez A, et al. This site needs JavaScript to work properly. Martora F, Battista T, Marasca C, Genco L, Fabbrocini G, Potestio L. Clin Cosmet Investig Dermatol. Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature. Drago F, Ciccarese G, Rebora A, Parodi A. Our expert physicians and surgeons provide a full range of dermatologic, reconstructive and aesthetic treatments options at Cleveland Clinic. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. Involvement of the oral mucosa has also been reported in as many as 50% of all cases (11). I put on some hydrocortisone and went to sleep, then woke up with another mark on my side, a couple inches below my armpit. 2021;185(2):e34. -. Published by Elsevier Inc. Pityriasis rosea. Although histopathologic characteristics of PR are also observed in PR-like lesions, the presence of dyskeratotic keratinocytes, interface dermatitis, and eosinophilic infiltration in the dermis may be more prominent in PR-like eruptions (11). Clipboard, Search History, and several other advanced features are temporarily unavailable. Clipboard, Search History, and several other advanced features are temporarily unavailable. PMC In darker-skinned or Black people, the patches may be more raised (papular), and the centers of the patches may look like the tissue is dying (necrotic). Get many smaller patches or bumps on your skin. Keywords: adverse effect, coronavirus, cutaneous eruptions, immunization, pityriasis rosea, SARS-CoV-2, vaccine, case report, Citation: Leerunyakul K, Pakornphadungsit K and Suchonwanit P (2021) Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination. Some people see the rash disappear within 6 to 8 weeks, but it can take 5 months or longer for the skin to clear. Department of Dermatology, Graduate School of Medicine, Kyusyu University, Japan. Pityriasis rosea is a rash that usually appears on the torso, upper arms, thighs or neck. The papillary dermis shows melanin incontinence, perivascular lymphocytic infiltrate and rare scattered extravasated red blood cells.
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