15 February 2013. Students rotate through the various clinical settings on the campus, and primary care centers and specialty care centers located throughout Jacksonville. Thank. A.D.A.M. Symptoms will be treated as appropriate. Heres an ABC News segment on the case: As Ryan Miller reported for the Greenville News, the 53-year-old Clayton pled guilty tovoluntary manslaughter and tampering with a food or drug after she admitted togiving her husband Steven Clayton drinks laced with Visine.. Reza, H.G. In general, be careful about using such eye drops, even if they go where they are supposed to go. The active ingredient in Visine eye drops is Tetrahydrozoline HCI 0.05%. Tetrahydrozoline poisoning occurs when someone accidentally or intentionally swallows this product. TETRAHYDROZOLINE (tet-ra-hye-DROZ-oh-leen) is a decongestant. Products containing tetrahydrozoline can interact with many prescription drugs. The teen could have faced 10 years in prison if she were to go to trial and found guilty. Then his wife admitted to poisoning his water with eye drops. We report a case of unintentional tetrahydrozoline ingestion with cardiovascular . When consumed by mouth, they may result in serious toxicity and even death. Many of these types of OTC products do not have child-resistant closures, so they should be stored out of the reach of children. Symptoms of tetrahydrozoline poisoning include: Blood pressure changes; Nausea; Vomiting; Seizures; Coma; Difficulty breathing; Xiidra does not contain tetrahydrozoline, but is still considered potentially harmful when swallowed. state Department of Insurance said when announcing his arrest last month. In 2001, a 22-year-old college student from Wisconsin was jailed for 90 days for repeatedly pouring eye drops into her roommates water after seeing the prank in the comedy Wedding Crashers. Adverts are the main source of Revenue for DoveMed. [Milwaukee] Journal Sentinel. Foreign objects like batteries and toys. As this ABC News segment described, he allegedly used Visine eye drops to poison and eventually kill his wife, 32-year-old Stacy Robinson Hunsucker: Per the news segment, Hunsucker and his wife had been high school sweethearts. UpToDate. . Also offered on campus is an American Society of Health-System Pharmacists-accredited pharmacy residency program at Shands Jacksonville. 16 September 2008. It also figures in murder charges against Joshua Lee Hunsucker, a North Carolina paramedic accused of killing his wife, Stacy Hunsucker, 32, in 2018, allegedly for life insurance money, the state Department of Insurance said when announcing his arrest last month. The active ingredient in eye drops such as Visine is tetrahydrozoline HCI. Pl drop the argument as it. You can thank tetrahydrozoline for helping do this. Also, the mental image of an enemy sent hotfooting for the toilet is a hugely satisfying one, especially in a society that views fecal output as something to be ashamed of. A 19-year-old Wyoming woman accused of poisoning her stepmother with eye drops has pleaded no contest to an aggravated assault charge. It can also lead to a drop in body temperature, a coma, and, of course, death. 7 September 1997 (p. A32). Tetrahydrozoline is a form of a medicine called imidazoline, which is found in over-the-counter eye drops and nasal sprays. is also a founding member of Hi-Ethics. We present a case of tetrahydrozoline ingestion in an adult who presented with chest pain, bradycardia, mental status depression, miosis, and other signs and symptoms of imidazole compound poisoning. Answered Apr 20, 2022. The Lancet. Tetrahydrozoline causes constriction of blood vessels when it is applied directly on the eye; this reduces eye redness. The victim, Rudy Trabanino of Houston, became violently ill and had to be hospitalized for several days with acute pain and a variety of serious medical problems. Also, dont believe the full-of-poop claims that such eyes drops can be a way of giving someone explosive diarrhea. But most importantly dont put Visine eye drops in someones drink. Imidazolines (like oxymetazoline and tetrahydrozoline) are commonly found in over-the-counter eye drops and nasal sprays. I will drop in updates here accordingly. Not your mouth or other orifices. She was a manager at Pizza Hut in 2011, when a disgruntled co-worker spiked her soda with eye drops. A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). 2020 Jan 18. Symptoms of an overdose of tetrahydrozoline include drowsiness, slow breathing or absence of breathing, slow heartbeat, hypothermia and possibly even coma. In: Burns MM, ed. While poisoning symptoms are uncommon after applying the drops to the eyes, these agents can produce significant poisoning if taken orally. Visine is clearly labeled for external use only and should never be swallowed., This is a BETA experience. Tetrahydrozoline Poisoning is the accidental or intentional intake of medication containing tetrahydrozoline. While poisoning symptoms are uncommon after applying the drops to the eyes, these agents can produce significant poisoning if taken orally. Visine eye drops are a commonly used topical drug for irritation of the eye. It reduces redness in the eye caused by minor eye irritations. Swallowing this substance can result in a number of nasty effects, including: Pfizer's cautions to users of Visine include: "If swallowed, get medical help or contact a Poison Control Center right away." Unintentional pediatric ophthalmic tetrahydrozoline ingestion: case files of the medical toxicology fellowship at the University of California, San Francisco. Approved by: Krish Tangella MD, MBA, FCAP. Learn more about A.D.A.M. In general, sleepiness or drowsiness are symptoms of concern if children particularly those below the age of 6 consume more than 1 milliliter in a day., Clinical pharmacologist and president of PharmaLogic Development, Inc., Gary Novack, PhD, agrees. Stars and Stripes. Los Angeles Times. Steve and Lana Clayton lived . The Washington Post. Tetrahydrozoline poisoning occurs when someone accidentally or intentionally swallows this product. The resulting symptoms are nothing, nothing at all like the Hollywood version of events. The UF College of Nursing continually attracts and retains the highest caliber of nursing students and faculty with a passion for science and caring. I felt awful," she told Inside Edition. This will help them in assessing the possible drug interactions within various medications and help avoid/prevent accidental or unintentional toxic drug effects. Tetrahydrozoline or tetryzoline is an alpha agonist (substances that help blood vessel constriction) found in certain eye drops and nasal solutions, It is an over-the-counter medication that is commonly used for children and adults. 7, pp. She pleaded guilty to a lesser charge of voluntary manslaughter and was also sentenced to a tampering charge with a 20-year concurrent sentence, the filings show. "Crater Lake Worker Called Visine Poisoning a 'Harmless Prank.' They include rapid heart beat, nausea,. Take the container with you to the hospital, if possible. As the two cases demonstrated, even relatively small amounts can be toxic. Symptoms will be treated as appropriate. "Airman Sentenced to Life in Prison." 16th ed. UpToDate. DrugFacilitated Sexual Assault Using Tetrahydrozoline. Dont crash weddings to hook up with strangers. And do not put eye drops in anyones drink, even just a few drops to prank someone. While it is true that Visine is readily obtainable (it's an non-prescription eye drop manufactured by pharmaceutical giant Pfizer), a drink spiked with it is not a sure-fire means of producing diarrhea in the one unfortunate enough to swallow it, and ingestion of such a concoction is downright dangerous, making this "harmless" form of retaliation fraught with hazard. The mouth may have a metallic taste and the breath emits a garlic type of odor. All medications can have side effects. The woman, whose name is not been released, suffered from numerous different symptoms that had sent her to the hospital on two separate occasions, but doctors were struggling to diagnose her illness. She had suffered from PTSD attributed to domestic abuse, he said. It should never be ingested for the consequences can even be fatal The amount will vary, even a small amount can be lethal. Swallowing this substance can result in a number of nasty effects, including: Coma Difficulty breathing or no breathing Blurred vision, change in pupil size Blue lips and fingernails Fast or slow heartbeat, changes in blood pressure (high at first, low later) Headache The Washington Post. Journal of Forensic Medicine and Toxicology, 29(1), 80-92. DO NOT use it to treat or manage an actual poison exposure. The girlfriend later discovered that Carpenter had been texting his friends to boast about the eye drops prank and called the police on him. If the victim is not breathing, perform mouth-to-mouth resuscitation. Others in the class who saw the act removed the adulterated beverage before the intended victim could drink it. Waltham, MA: Elsevier; 2016:793. The girl later told police that she got the idea to use the eye drops as poison from an unrelated news story. 10 Hemlock. The active ingredient in eye drops such as Visine is tetrahydrozoline HCI. Several systems of the body, such as the respiratory system, digestive system, nervous system, and ENT may be affected. She admitted to doing this deliberately and surreptitiously. This article is for information only. Many of these types of OTC products do not have child-resistant closures, so they should be stored out of the reach of children. A.D.A.M. In Patient Centered Medicine. Young children who consume small amounts of tetrahydrozoline (as little as one-half of one teaspoon) can develop sleepiness and difficulty breathing. Although this belief has been around for decades, and everyone knows someone who knows someone who really did administer a Visine mickey to a deserving miscreant and thereby caused him an immediate serious case of the trots, there's no documented evidence the producthas that effect. Spiller, H. A., & Siewert, D. J. Products containing tetrahydrozoline can interact with many prescription drugs. The person may receive: Survival past 24 hours is usually a good sign that the person will recover.Some individuals may have long-lasting complications if multiple organs are damaged by the drug. It could be from seasonal allergies, being tired, or smoking marijuana, for example. This article is for information only. The smaller the body size, the less thats needed to cause major problems and even be life threatening. Commonly used drops marketed to reduce redness in the eyes typically contain tetrahydrozoline, which was approved by the U.S. Food and Drug Administration (FDA) in 1954 and belongs to a family of drugs called imidazoles. Products like Visine contain tetrahydrozoline HCI, according to http://Healthguidance.org, and this substance is known to cause diarrhea, nausea, severe breathing difficulty, respiratory failure, tremors, blurred vision, seizures, coma and even death. How Visine eye drops in the mouth can kill, here are two cases. In Clinical Toxicology (Vol. 4 Available since the 1950s, tetryzoline is a selective 1-receptor agonist 5 that is used as an ocular and nasal decongestant. It matters not if actual harm results from the attempt the act itself is enough to land one in the hoosegow. 35; pp. Tetrahydrozoline, a form of medicine found in many over the counter eye drops such as Visine, can cause seizures, blurred vision, difficulty breathing and may even result in a coma if taken. The active component in Visine eye drops is tetrahydrozoline. Lana Sue Clayton was sentenced to 25 years in prison after she added eye drops to her husbands drinks in such large amounts that the active chemical killed him, according to the authorities. (2016). The defendant initially pleaded not guilty to the charge, but had a change of heart this week. Dont say that people use only 10% of their hearts when you reveal only 10% of your true identity. In: Aronson JK, ed. Aronson JK. Jennings later told investigators that the woman had ingested about five bottles worth of Visine that day. Such imaginings give us the chance to vicariously experience the joys of retribution, joys we're not likely to sample in real life, such as the following: I've heard that barmaids and cocktail waitresses have a secret for getting rid of obnoxious customers. Tetrahydrozoline or tetryzoline is an alpha agonist (substances that help blood vessel constriction) found in certain eye drops and nasal solutions. Its use in greater than recommended doses may cause hypertension, bradycardia, rebound hypotension, and possibly arrhythmias. If it is established that a person is a regular drug user, then raise the number of milligrams for MLD by 33%. York County Sheriff's Office, via Associated Press. In March 2013, a 27-year-old mechanic named Shayne Carpenter was arrested in Grass Valley, California, for putting eye drops in his girlfriend's drink after an argument with her, causing her to feel ill. As the North Carolina Department of Insurance (NCDOI) indicated, these circumstances led to an investigation by the NCDOI, the Gaston County (NC) Police Department, and Homeland Security Investigations (HSI) that then resulted in allegations of fraudulent life insurance claims. You should call if you have any questions about poisoning or poison prevention. 13 March 2013. DO NOT make a person throw up unless told to do so by poison control or a health care professional. Both options are free, expert, and confidential. A 33-year-old Pennsylvania woman could spend the rest of her life in prison after admitting to police that she repeatedly poisoned her boyfriend with Visine eye drops for more than three years in . If you or someone you are with has an exposure, call the local emergency number (such as 911), or the local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. Everyone who has ever been wronged has at one time or another felt the urge to strike a counterblow. Lowering body temperature to dangerous levels, Making breathing difficult, or even halting it entirely, Elevating and then dropping blood pressure, In 1995 an adult customer at a Whole Foods market (a retail chain of natural and organic foods) had his wheat-grass smoothie spiked with a bottle of Visine by a clerk intent upon playing a practical joke. Tetrahydrozoline, a derivative of imidazoline, is widely used for the symptomatic relief of conjunctival and nasal congestion; however, intentional or unintentional high doses can result in toxicity manifested by hypotension, tachycardia, and CNS depression. 9 January 2009. Learn how we can help. Before we move further to the symptoms of poisoning and analyze the tests required for its treatment, it's essential to understand the causes and risk factors that can lead to poisoning. Medical Toxicology Physician, Call It was said in court that she admitted to putting eye drops in his water, Leslie Robinson, assistant solicitor for York County, said in an interview on Friday. Acetaminophen. You may opt-out by. The clerk responsible for the act was dismissed, and Whole Foods Market settled out of court with Trabanino for an undisclosed sum after he brought a. The products contain the active ingredients tetrahydrozoline, naphazoline, or oxymetazoline. Vaso stands for vessel as in blood vessel and constrictor means make more narrow. When blood vessels become more narrow, less blood can flow through them. This material may not be reproduced without permission. The following information is helpful for emergency assistance: However, DO NOT delay calling for help if this information is not immediately available. "Investigator Testifies That Airman Confessed to Eskew Killing." If tetrahydrozline is in someones drink while drinking alcohol . Fifty-three cases reported hospitalization due to symptoms including nausea, vomiting, lethargy, tachycardia, decreased respiration, bradycardia, hypotension, hypertension, sedation, somnolence,. The Dangers of Letting Your Dog Play in the Ocean, Ex-'Top Chef' Contestant Accused of Poisoning Tree That Was Blocking Solar Panels, Woman Who Allegedly Poisoned Niece's Breast Milk Didn't 'Feel an Ounce of Guilt,' Cops Say, Bride Sues Caterer After Guests Suffer Food Poisoning During Wedding. He was found dead in the homeon July 21. The victim spent several days in the hospital recovering from reactions to the poisoning that included a dangerously low heart rate and blood pressure. ; Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may . Our state-of-the-art medical center serves an urban population of 1 million from north Florida to south Georgia. It would be helpful if the following information is readily available: Type, dosage and time of administration of medication, And, the overall health status of the individual. Find patient medical information for tetrahydrozoline ophthalmic (eye) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Stars and Stripes. Symptoms of an overdose of tetrahydrozoline include drowsiness, slow breathing or absence of breathing, slow heartbeat, hypothermia and possibly even coma. 14 November 2006. stinging or burning of the eye blurred vision increased eye redness or irritation If you experience any of the following symptoms, stop using tetrahydrozoline eye drops and call your doctor immediately: headache sweating fast or irregular heartbeat nervousness Seek medical help right away. Generic Name Tetryzoline DrugBank Accession Number DB06764 Background. We report a case of unintentional . 52, No. Medical literature reports other cases of small children brought to the brink of crisis by ingestion of tiny amounts of over-the-counter eye drops. When investigators contacted the husband he reported experiencing stomach problems for the past two months, and poison control personnel informed a detective that ingesting too much Visine "would put a person in a coma with several other serious symptoms. Many of these types of OTC products do not have child-resistant closures, so they should be stored out of the reach of children. We offer a a four-year Doctor of Veterinary Medicine programs as well as M.S. This symptom is a precursor to difficulty speaking. According to figures provided in an email by the American Association of Poison Control Centers, there were no reported deaths from tetrahydrozoline from 2016 through 2019. "Generally, symptoms can occur in as little as one hour, peaking at eight hours, and resolving . Reports of significant toxicity from tetrahydrozoline ingestion are unusual but have occured primarily in small children after unintentional ingestion (3-63, 6). Always read the label before using any over-the-counter (OTC) product. "Pa. Woman Gets 2-4 Years for Poisoning Man with Visine." 19 September 1997 (p. A30). You can call for any reason, 24 hours a day, 7 days a week. These medications are available over-the-counter in pharmacies in the United States and are frequently not packaged in child-resistant containers. Updated by: Jacob L. Heller, MD, MHA, Emergency Medicine, Emeritus, Virginia Mason Medical Center, Seattle, WA. Ginger Watson knows what it is like to be poisoned by eye drops. More than 1,600 cases of oral exposures are reported to United States poison centers annually (1,2). 746-746). If you suspect someone has ingested tetrahydrozoline, do not try to make the person vomit it back up as that may actually increase their absorption of the chemical. I felt awful, she told Inside Edition. You can call for any reason, 24 hours a day, 7 days a week. Apparently, her death had a sweetheart of an insurance pay-out: $250,000. In addition to death, ingesting tetrahydrozoline can cause "drowsiness, slow breathing or absence of breathing, slow heartbeat, hypothermia and possibly even coma." After his wife's death,. Tetryzoline is found in a wide array of over-the-counter . Lowry, J. The Turkish journal of pediatrics, 54(6), 658. Symptoms Symptoms may include: Coma Difficulty breathing or no breathing Blurred vision Blue lips and fingernails Change in pupil size Changes in blood pressure (high at first, low later) Fast heartbeat Headache Irritability Low body temperature Nausea and vomiting Nervousness Seizures Tremors (unintentional trembling) Home Care Clayton's family released a statement on the allegations against his wife. The health care provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. Swallowing eye drops containing tetrahydrozoline is harmful and potentially life-threatening. A few drops of Visine brand eye drops taken internally will induce uncontrollable diarrhea. Exposure is common in young children, who unintentionally ingest it, but cases have been rising in the adult population. Help is available online with web POISON CONTROL or by phone at 1-800-222-1222. Symptoms Symptoms may include: Altered mental state Coma (lack of responsiveness) Difficulty breathing or no breathing Blurred vision Blue lips and fingernails Changes in blood pressure (high at first, low later) Change in pupil size Fast or slow heartbeat Headache Irritability Low body temperature Nausea and vomiting Nervousness, tremors Seizures Lana Sue Clayton in a 2018 booking photo. Teenagers and adults who drink larger amounts may also experience heart rhythm abnormalities and breathing problems that can be life-threatening. Both options are free for the public, and available 24 hours a day. This national hotline will let you talk to experts in poisoning. Associated Press. That is why we provide online Continuing Medical Education (CME) courses for you to complete for CME credits. Are one or two dangerous? Founded in 1956, the University of Florida College of Nursing is the premier educational institution for nursing in the state of Florida and is ranked in the top 10 percent of all nursing graduate programs nationwide. "Central Nervous System Depression Following Accidental Ingestion of Visine Eye Drops." 2018 Sep 5. The symptoms of a suspected poisoning may vary depending on the person's age, the type of poisonous substance, the amount of poison involved, and how much time has passed since the poisoning occurred. Keep in mind that such eye drops primarily help with your appearance but do not necessarily address whats actually causing the redness. DO NOT make a person throw up unless told to do so by poison control or a health care professional. Further, any substance ingested in a sufficient quantity can likewise be toxic. Included in the symptoms are vomiting, blurred vision, rapid heartbeat, and difficulty breathing. [New York] Newsday. Nardo, Melissa. In the past two years, there have been three separate criminal cases involving Visine. When used in high amounts or when ingested, tetrahydrozoline can also cause sleepiness, low blood pressure, and a dangerously slow heart rate. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Stephen Clayton, a millionaire businessman,lived with his wife in a South Carolina mansion that is a replica of George Washington's Mount Vernon plantation. Constricting blood vessels in your eyes is how they get the red out., The FDA considers the risk for these products to be low as they are labeled for external use only and are clearly marked keep out of reach of children.. Intentionally or accidentally drinking eye drops can lead to toxic blood levels. As a subscriber, you have 10 gift articles to give each month. Flynn, George. , updated The following information is helpful for emergency assistance: However, DO NOT delay calling for help if this information is not immediately available. Munchausen syndrome by proxy due to tetrahydrozoline poisoning. Young children who consume small amounts of tetrahydrozoline (as little as one-half of one teaspoon) can develop sleepiness and difficulty breathing. Tetrahydrozoline is sold under the following brand names: Note: This list may not be all inclusive. Its use in greater than recommended doses may cause hypertension, bradycardia, rebound hypotension, and possibly arrhythmias. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. So if youve got children or very small actors around, make sure that you keep eye drops safe and secure. According to Michael Banks, reporting for the Shelby Star, Hunsucker had resisted an autopsy being done before his wifes body was cremated. Such interactions may enhance the therapeutic effects of the drug or other medications being taken, resulting in undesired side effects (such as an overdose). The student responsible has been charged with tampering with a drink with intent to cause harm. The drug may be sold under brand names Eyesine, Geneye, Murine Tears Plus, Optigene 3, Tyzine, Visine Original and Advanced Relief among others, Tetrahydrozoline Poisoning is the accidental or intentional intake of medication containing tetrahydrozoline, The condition is diagnosed based upon the clinical history, combination of signs and symptoms, and additional tests (that may include, in some cases, radiological studies and laboratory tests), Tetrahydrozoline Poisoning is caused by the intake of large amounts of tetrahydrozoline containing medicated solutions, This intake could be accidental, or in some cases intentional, to bring self-harm, Breathing difficulties; absence of breathing, Vision abnormalities including blurred vision; dilated pupils, Bluish discoloration of lips and beneath fingernails, If the individual with Tetrahydrozoline Poisoning is in a coma, or is experiencing life-threatening symptoms, call 911 (or your local emergency help number) immediately, Call the Poison Control Center at 1-800-222-1222 (or your local poison control center) for further instructions, Provide them with information such as dosage, type of drug taken, strength and time of ingestion of medication, age, weight and general health status of affected individual, Confirm that the airways are protected; also, ensure breathing and the presence of pulse, Unless instructed by a healthcare professional, DO NOT induce vomiting in the affected individual, Take individual to emergency room (ER) for further treatment, Always try to take the medication strip/bottle/container to the ER, Medically manage symptoms; provide breathing support, if necessary, Administer activated charcoal to avoid absorbance of drug in the body, Administer laxatives for elimination of drug from the body, Administer fluids by an intravenous drip line, The individual who overdosed, or someone near, should call 911 for emergency assistance (or the local emergency number), They should also call the poison control center at 1-800-222-1222 (or the local poison control center) and follow instructions, The prognosis of Tetrahydrozoline Overdose is dependent on the amount of drug consumed, time between ingestion and treatment, severity of the symptoms, as well as general health status of the patient, If the individual can recover from the symptoms within a period of 24 hours, with adequate medication and support, the outcome is generally good, In case of severe symptoms including abnormal heart-rates, seizures, and coma, it may considerably worsen the outcome. . The Clayton case is the latest involving fatal amounts of ingested tetrahydrozoline. Lee BY. Police say she poisoned him- with eye drops. Most recently, a California man was arrested a week ago and charged with trying to poison his girlfriend by lacing her drinks with the eye drops. The person may receive: Survival past 24 hours is usually a good sign that the person will recover. WOIO-TV [Cleveland]. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. WPVI-TV [Philadelphia]. Visine side effects. In October 2003, an unnamed Southern California high school student put eye drops in teacher's water bottle in an attempt to give his instructor severe diarrhea. WRIC-TV [Richmond]. Lasala, G. S., Vearrier, D., Boroughf, W. J., & Osterhoudt, K. C. (2014, August). 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